We are all aware of the fact that slimming can be a mega-dollar industry. With millions, or else huge amounts of people of any age struggling to lose weight, and incredibly few pharmaceutically effective medications available to assist them, the desperate public will literally clutch at straws.
Per week sees the launch of your new “miracle” weight loss pill or potion plus a “surefire” diet certain to help believers shed kilos like magic.
Recently garcinia cambogia dr oz became the flavour of the season. Should you search the world wide web for facts about this exotic fruit extract you will certainly be assured this is finally the miracle many of us have been waiting for, that will produce dramatic weight-loss. Endorsements by various TV personalities along with other luminaries have included with the allure of Garcinia cambogia slimming products.
According to a recently available local study from the Tshwane University of Technology (TUT) “this small fruit, reminiscent of a pumpkin in looks, is currently most popularly used and widely advertised being a weight-loss supplement”.
The comprehensive overview from TUT implies that studies show that “the extracts and also (-)-hydroxycitric acid (HCA), a primary organic acid element of the fruit rind, exhibited anti-obesity activity”. Furthermore, it regulates the serotonin levels associated with satiety, leading to reduced intake of food.
“Based on clinical trial reports, Garcinia extracts were good for obese individuals most of the time. In addition, studies around the toxicity and observations during clinical studies indicate that Garcinia is safe for use. Most of the negative reports are already linked to cases when multi ingredient formulations were consumed as well as the effect could not be attributed to a specific ingredient.”
The study does, however, caution against a rise in serotonin, especially in those who take medicines that are already increasing serotonin levels, like SSRIs. Research in to these effects is not conducted.
“Moreover, regulatory authorities must provide and enforce legislation requiring the compulsory basic safety illustration showing supplements pre-marketing and develop post-marketing surveillance systems,” the analysis concluded.
Dr Ingrid van Heerden, a registered dietitian, is of opinion that people needs to be cautious of garcinia cambogia extract, because it has not undergone rigorous testing. What follows is reviewed information from her pen, including her final verdict:
Often, once a person who wants, or needs to lose weight, is totally hooked on the promise of a slim, sexy figure, they may be sucked in to the deception. If the drops, wafers or powders don’t work, well then it is the fault of the user who failed to abide by one or some other often impossible instruction for example “stick into a 500 kcal/day diet” or “drink 5 litres water a day”, never that of the diet plan pill.
When eventually science and legislation meet up with the makers, they calmly take product A from the market, change their formulation slightly, change the name to product B, after which blithely sell product B using the same advertising gambits as before, raking in the money and pulling the wool over everyone’s eyes once again.
In line with the ever-changing slimming product ranges, you will find what you can call “ingredients of the year” (sometimes an ingredient can last for only 3 to 6 months, however some have longer life spans, then obviously some are resurrected every 2-3 years).
We have had apple cider vinegar (which includes made many a comeback over time), green tea extract (which contains earned some merit in scientific research), hoodia (which just will not find a way to produce the research results that will make it a front-runner), willow bark (or salicylic acid which will work for aches and pains although not as efficacious for slimming), and traditional caffeine (that features a diuretic effect thus assisting you lose fat until you replenish this type of water in the body, plus a stimulant effect when taken in large quantities that can be potentially dangerous), to mention but several.
Though it may be perfectly entirely possible that more extensive and well controlled scientific tests will disclose that an extract of Garcinia cambogia that contains a chemical called hydroxycitric acid (HCA) can assist fat loss, we are currently not even sure how this tamarind or brindall berry or brindleberry or Garcinia gummi-gutta works, what side-effects it may or may not have and what dosage must achieve really significant weight loss.
Having Said That I hear you say: “For once there exists a number of scientific studies which were conducted with Garcinia cambogia, so what’s the issue?”
Well several of the studies failed to show any weight-loss differences between patients who took Garcinia pills and people who took dummy pills, while other studies did show variations in weight-loss with all the subjects taking pills containing Garcinia losing a little more weight than others that did not (Marquez et al, 2012).
A number of these fat loss differences were not exactly exciting either, so that we can’t say for sure that Garcinia cambogia does promote weight-loss. Additionally, it seems likely that this may not be the wonder pill it can be made in the market to be.
Furthermore, many of the studies conducted to date happen to be flawed (Critchley, 2013) . What it means is for example that in just one study the control and experimental subjects were not well matched (i.e. they was without the identical starting weight, age, portion of body fat etc.), whilst in other studies too few subjects were used for that leads to be significant.
For that results of studies to become plausible one must compare “apples with apples” (i.e. well-matched subjects and controls) and you need more than simply a few subjects to produce the identical result.
On the positive side, we can say that there exists some evidence that Garcinia cambogia products may aid fat loss over a duration of 12 weeks. No studies have been conducted for prolonged periods as yet (Marquez et al, 2012), which is also viewed as a drawback.
There is also at present an argument regarding the safety of pills containing Garcinia cambogia – one band of researchers slates the pills as dangerous and hepatotoxic (causing liver damage) (Kim et al, 2013), while another group refutes this (Clouatre & Preuss, 2013). Marquez with his fantastic coworkers (2012) declare that “at the doses usually administered, no differences have been reported in terms of side effects or adverse events (those studied) in humans between individuals cured with G. cambogia and controls.”
Ano Lob (2009), a public health consultant in the states has published a stern warning regarding the hepatotoxicity of a weight loss product called “Hydroxycut”, that contains Garcinia cambogia. The author collected case reports of patients who developed liver toxicity of the aforementioned weight loss product.
Evidently approximately one million units on this hydroxycitric acid product can be bought each year in the united states. The patients who developed hepatotoxicity reported signs and symptoms of fatigue, nausea, vomiting, cramps, fever, chills, abdominal pain, and jaundice.
While the amount of hepatotoxicity cases reported were only a few, Lob indicates that monitoring of adverse events connected with vitamin supplements like these weight-loss products is woefully inadequate in America (as is the case in numerous other countries, including South Africa), with the FDA only receiving about 1% of those negative reports.
In accordance with Lob (2009), the Poison Control Centres in the USA are more inclined to receive reports of adverse events related to dietary supplements but are not equipped to coordinate such findings.
He cites the truly sobering illustration of an item called “Metabolife 356″ which had been sold as a fat loss supplement in America. Lob’s states that this manufacturers received 14 000 reports over a duration of five-years that documented “serious adverse events connected with their ephedra-containing product” which dexrpky17 heart attacks, strokes, convulsions and fatalities.
The manufacturers failed to inform the FDA or some other US government authority of those reports. As astounding because this may sound, manufacturers of dietary supplements usually are not expected to meet the specifications which are strictly enforced with regards to food and pharmaceutical products (medicines), so they can utilize this “ethical loophole” to never publish reports of negative and harmful events.
Eventually these events stumbled on light and ephedra-containing products for slimming along with other uses were banned in the USA.
The implication contain in Lob’s warning is that HCA or Garcinia cambogia extract will also be potentially toxic unless sufficient, reliable evidence towards the contrary is produced available.
In the present moment, we do not know enough about slimming products that contain possible side effects of garcinia cambogia to freely recommend its use. I have a tendency to go along with Astell and coworkers (2013) who conducted a systematic article on double blind randomised controlled clinical trials to assess evidence available on the efficacy of current dietary supplements used to control appetite or weight.
These authors determined that “According towards the finding using this systematic review, evidence is not convincing in demonstrating that many nutritional supplements used as appetite suppressants to lose weight in the treating of obesity work well and safe.”
While we wait around for more extensive and conclusive evidence obtained with larger quantities of well-matched test subjects treated for prolonged periods with all the “gold standard” of double blind randomised controlled clinical studies, rather stay away from any weight-loss supplement that has not been tested thoroughly.